Fluorescence Spectroscopy – A More Reliable Screening Method Than Guthrie Test

Fluorescence Spectroscopy – A More Reliable Screening Method Than Guthrie Test

Fluorescence spectroscopy is another PKU screening method which measures the phenylalanine (Phe) level in the blood. This type of electromagnetic spectroscopy analyzes fluoroscence from a blood sample, which is exposed to a beam of (usually) ultraviolet light.

Dr. Richard Koch – The Main Catalyst For “Low Protein Diet For Life” Policy

Dr. Richard Koch – The Main Catalyst For “Low Protein Diet For Life” Policy

Dr. Koch was the main investigator of the original (The Collaborative Study of Children Treated for Phenylketonuria (PKUCS)) study designed to answer an questions whether is it safe to stop the low protein diet in childhood or not.

Tandem Mass Spectrometry – The Most Reliable PKU Test

Tandem Mass Spectrometry – The Most Reliable PKU Test

Tandem mass spectrometry is using tandem mass spectrometers – instruments that have more than one analyser and can quickly sort biochemically molecules of similiar weight. PKU screening test with Tandem mass spectrometry method is more reliable than other tests and reduces the number of falsely positive PKU results.

PKU Test – What Are The Normal Phe Levels?

PKU Test – What Are The Normal Phe Levels?

For healthy individuals, the normal blood phenylalanine level is usually around 1mg/dL.

PKU patients, however, may have different Phe levels in their bodies, ranging from 6 – 30+ mg/dL.

Phenylpyruvic Acid – A Clear Indicator Of PKU Disorder

Phenylpyruvic Acid – A Clear Indicator Of PKU Disorder

Phenylpyruvic acid, discovered in 1934. by Dr. Ivar Asbjørn Følling, is found in phenylketonuria patients’ urine and is a clear indicator of PKU disorder.

PKU patients lack PAH enzyme and are unable to convert phenylalanine into tyrosine, which enables phenylalanine to acumulate within the body.

Dr. Horst Bickel – Leader Of PKU Revolution

Dr. Horst Bickel – Leader Of PKU Revolution

German doctor Horst Bickel (1918. – 2000.) was responsable for discovering the first dietary therapy for phenylketonuria (PKU) patients. Nutritional formula, discovered by Dr. Bickel and his colleagues in 1951., improved the life quality of thousands of PKU patients, helping them to lead a normal and healthy life.