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Phenylpyruvic Acid – A Clear Indicator Of PKU Disorder

Phenylpyruvic acid, discovered in 1934. by Dr. Ivar Asbjørn Følling, is found in phenylketonuria patients’ urine and is a clear indicator of PKU disorder.

PKU patients lack PAH enzyme and are unable to convert phenylalanine into tyrosine, which enables phenylalanine to acumulate within the body.

Accumulated phenylalanine is then metabolised by various metabolites to phenlypyruvic acid. Few years after Dr. Følling’s discovery, phenylketonuria disorder finally got its’ official name due to phenylpyruvic acid found in patients’ urine samples.

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