Fluorescence spectroscopy is another PKU screening method which measures the phenylalanine (Phe) level in the blood. This type of electromagnetic spectroscopy analyzes fluoroscence from a blood sample, which is exposed to a beam of (usually) ultraviolet light.
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Tandem mass spectrometry is using tandem mass spectrometers – instruments that have more than one analyser and can quickly sort biochemically molecules of similiar weight. PKU screening test with Tandem mass spectrometry method is more reliable than other tests and reduces the number of falsely positive PKU results.