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Fluorescence Spectroscopy – A More Reliable Screening Method Than Guthrie Test

Fluorescence spectroscopy is another PKU screening method which measures the phenylalanine (Phe) level in the blood. This type of electromagnetic spectroscopy analyzes fluoroscence from a blood sample, which is exposed to a beam of (usually) ultraviolet light. Ultraviolet light then excites the electrones of certain compounds and cause them to emit light that is usually visible. This process is more reliable than Guthrie test and it’s done with fluorometer, a device used for measuring different fluoroscence paramaters.

Want to learn more?


“The PKU Paradox: A Short History of a Genetic Disease” by Diane B. Paul and Jeffrey P. Brosco.

“Robert Guthrie–The Pku Story: Crusade Against Mental Retardation” by Jean Holt Koch.

“Low Protein Cookery for Phenylketonuria” by Virginia E. Schuett.

“Low Protein Food List for PKU” by Virginia E. Schuett.

“Low Protein Bread Machine Baking for PKU” by Virginia E. Schuett.

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